To create a site-to-site VPN using the Boto3 library in Python, you can utilize the boto3.client('ec2') client to interact with the AWS EC2 service. Here’s an example code snippet to create a site-to-site VPN:

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import boto3

ec2_client = boto3.client('ec2')

# Create VPN Gateway
vpn_gateway_response = ec2_client.create_vpn_gateway(Type='ipsec.1', TagSpecifications=[{
    'ResourceType': 'vpn-gateway',
    'Tags': [{'Key': 'Name', 'Value': 'SiteToSiteVPN'}]
}])
vpn_gateway_id = vpn_gateway_response['VpnGateway']['VpnGatewayId']

# Create VPN Connection
vpn_connection_response = ec2_client.create_vpn_connection(
    Type='ipsec.1',
    CustomerGatewayId='<CUSTOMER_GATEWAY_ID>',
    VpnGatewayId=vpn_gateway_id,
    Options={
        'StaticRoutesOnly': True
    },
    TagSpecifications=[{
        'ResourceType': 'vpn-connection',
        'Tags': [{'Key': 'Name', 'Value': 'SiteToSiteVPNConnection'}]
    }]
)
vpn_connection_id = vpn_connection_response['VpnConnection']['VpnConnectionId']

# Create VPN Connection Route
ec2_client.create_vpn_connection_route(
    DestinationCidrBlock='<DESTINATION_CIDR_BLOCK>',
    VpnConnectionId=vpn_connection_id
)

In the above code, you need to replace <CUSTOMER_GATEWAY_ID> with the ID of the customer gateway representing the remote site, and <DESTINATION_CIDR_BLOCK> with the CIDR block of the remote network you want to connect to.

The code snippet creates a VPN gateway using the create_vpn_gateway method, passing the desired parameters such as the type of VPN (Type) and tags (TagSpecifications). It then retrieves the VPN gateway ID from the response.

Next, the code creates a VPN connection using the create_vpn_connection method, providing the customer gateway ID, VPN gateway ID, options (in this case, StaticRoutesOnly), and tags.

Finally, the code creates a VPN connection route using the create_vpn_connection_route method, specifying the destination CIDR block and the VPN connection ID.

You can run this code using Python and the Boto3 library to create the site-to-site VPN resources in AWS EC2.